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This web site provides general information on traditional and innovative approaches to the design and analysis of clinical trials with multiple objectives, including multiple endpoints, multiple dose-control comparisons, multiple subgroups, etc.

See [[Index]] for a list of articles on the MultXpert web site.

== What is new? ==

Special issue of ''Journal of Biopharmaceutical Statistics'' on subgroup analysis in clinical trials (January 2014) guest-edited by Sue-Jane Wang (FDA) and Alex Dmitrienko (Quintiles). See [[Journal of Biopharmaceutical Statistics 2014]].

Presentations on multiplicity issues and subgroup analysis in clinical trials were given at the Joint Statistical Meetings in Montreal, QC on August 4-August 8, 2013. See [[Multiplicity Issues in Clinical Trials JSM 2013]].

Invited session on key multiplicity issues in clinical trials was held at the DIA Annual Meeting in Boston on June 24, 2013. See [[Key Multiplicity Issues in Clinical Trials DIA 2013|DIA 2013]].

Invited session on multiplicity issues in clinical trials was held at the SCT Annual Meeting in Boston on May 20, 2013. See [[Multiplicity in Clinical Trials SCT 2013|SCT 2013]].

[[Multiplicity Issues in Clinical Trials 2013]] was taught by [[Alex Dmitrienko]] at the ENAR conference in Orlando, FL on March 10, 2013.

Visit [[Updates]] to get more MultXpert updates. 

== Books ==

[[Multiple Testing Problems in Pharmaceutical Statistics]], edited by Dr. Alex Dmitrienko (Eli Lilly and Company, U.S.A.), Prof. Ajit C. Tamhane (Northwestern University, U.S.A.) and Dr. Frank Bretz (Novartis, Switzerland; Hannover Medical School, Germany) [Chapman & Hall/CRC Press 2009]. Available on [http://www.amazon.com/Multiple-Problems-Pharmaceutical-Statistics-Biostatistics/dp/1584889845/ Amazon's web site].

[[Multiple Comparisons Using R]], written by Dr. Frank Bretz (Novartis Pharma AG, Switzerland; Hannover Medical School, Germany), Prof. Torsten Hothorn (Ludwig-Maximilians-Universität München, Germany) and Prof. Peter Westfall (Texas Tech University, USA) [Chapman & Hall/CRC Press 2010]. Available on [http://www.amazon.com/Multiple-Comparisons-Using-Frank-Bretz/dp/1584885742/ Amazon's web site]. 
<!--== Multiplicity encyclopedia ==

We have started working on an online Wikipedia-type [[MultXpert Encyclopedia]] to provide information on traditional statistical methods as well as recent advances in the area of multiple comparisons.--> 

== Short courses ==

Visit [[Short Courses]] for information on recent and upcoming short courses on multiplicity and related topics.

== Software ==

Visit [[MultXpert package]] to learn about the new R package for implementing popular multiple testing and gatekeeping procedures

Visit [[Software]] to find out more about other free software for implementation of commonly used multiple testing and gatekeeping procedures

== Web site ==

This web site is maintained by a group of volunteers led by [[Alex Dmitrienko]].  We would like to thank the organizations that have generously provided funds to support this web site:

* Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Osaka.
* Applied Statistics Workshop.
* Trimodal Network.

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