This web site provides general information on traditional and innovative approaches to the design and analysis of clinical trials with multiple objectives, including multiple endpoints, multiple dose-control comparisons, multiple subgroups, etc.
See Index for a list of articles on the MultXpert web site.
What is new?
Subgroup Analysis in Clinical Trials ENAR 2012: Selected presentations given at the ENAR Conference in Washington, DC on April 2-4, 2012.
International Conference on Multiple Comparison Procedures 2011 held in Washington, DC on August 29-September 1, 2011.
Multiplicity Issues in Confirmatory Clinical Trials: Free online conference focuses on recent advances in the area of multiple comparisons, including methods for addressing complex multiplicity problems known as gatekeeping procedures.
Multiplicity Issues in Clinical Trials JSM 2011: Selected presentations given at Joint Statistical Meetings in Miami, FL on July 31-August 4, 2011.
Journal of Biopharmaceutical Statistics 2011: Special issue of Journal of Biopharmaceutical Statistics on multiplicity and adaptive design issues in pharmaceutical statistics (June 2011) edited by Dr. Alex Dmitrienko (Eli Lilly and Company) and Prof. Martin Posch (Medical University of Vienna) is now available online.
Visit Updates to get more MultXpert updates.
The MultXpert newsletter provides information on recent developments in the world of multiple comparisons with emphasis on clinical trial applications. To subscribe to the MultXpert newsletter, visit MultXpert Newsletter.
Multiple Testing Problems in Pharmaceutical Statistics, edited by Dr. Alex Dmitrienko (Eli Lilly and Company, U.S.A.), Prof. Ajit C. Tamhane (Northwestern University, U.S.A.) and Dr. Frank Bretz (Novartis, Switzerland; Hannover Medical School, Germany) [Chapman & Hall/CRC Press 2009]. Available on Amazon's web site.
Multiple Comparisons Using R, written by Dr. Frank Bretz (Novartis Pharma AG, Switzerland; Hannover Medical School, Germany), Prof. Torsten Hothorn (Ludwig-Maximilians-Universität München, Germany) and Prof. Peter Westfall (Texas Tech University, USA) [Chapman & Hall/CRC Press 2010]. Available on Amazon's web site.
Visit Short Courses for information on recent and upcoming short courses on multiplicity and related topics.
Visit MultXpert package to learn about the new R package for implementing popular multiple testing and gatekeeping procedures
Visit Software to find out more about other free software for implementation of commonly used multiple testing and gatekeeping procedures
This web site is maintained by a group of volunteers led by Alex Dmitrienko. We would like to thank the organizations that have generously provided funds to support this web site:
- Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Osaka.
- Applied Statistics Workshop.
- Trimodal Network.