Analysis of Multiple Endpoints in Clinical Trials 2008
Full-day course taught by Ajit Tamhane (Northwestern University) and Alex Dmitrienko (Eli Lilly and Company) at the Food and Drug Administration meeting in Silver Spring, MD on October 8, 2008.
Back to Short Courses.
Dmitrienko A, Molenberghs G, Chuang-Stein C, Offen W. Analysis of Clinical Trials Using SAS. SAS Press, 2005.
ZIP archives with SAS programs and macros for individual modules in this course can be downloaded from this page. After downloading the ZIP files, please extract the programs to the Course folder on the C drive.
Morning session: Multiple endpoints
SAS programs and macros to compute adjusted p-values and lower simultaneous confidence limits for the Holm, fixed-sequence and fallback tests in the cardiovascular trial example.
SAS programs and macros to carry out global and component tests and perform sample size calculations in the osteoarthritis trial example.
SAS programs and macros to carry out the Tamhane-Logan test in the Alzheimer's disease trial trial example.
Afternoon session: Gatekeeping procedures
Serial and parallel gatekeeping procedures
SAS programs and macros to compute adjusted p-values for serial gatekeeping procedures (Type II diabetes trial example) and parallel gatekeeping procedures (cardiovascular trial example).
Tree gatekeeping procedures
SAS programs and macros to compute adjusted p-values for tree gatekeeping procedure (hypertension and Type II diabetes trial examples).
For more information on software implementation of commonly used multiple testing procedures and gatekeeping procedures, see Implementation of Multiple Testing Procedures and Implementation of Gatekeeping Procedures.