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Analysis of Multiple Endpoints in Clinical Trials 2009

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Full-day course taught by Ajit Tamhane (Northwestern University) and Alex Dmitrienko (Eli Lilly and Company) at the 6th International Conference on Multiple Comparison Procedures in Tokyo, Japan on March 20, 2009.

Back to Short Courses.

SAS programs

ZIP archives with SAS programs and macros for individual modules in this course can be downloaded from this page. After downloading the ZIP files, please extract the programs to the Course folder on the C drive.

Morning session: Multiple endpoints

At-least-one procedures

SAS programs and macros to compute adjusted p-values and lower simultaneous confidence limits for the Holm, fixed-sequence and fallback tests in the cardiovascular trial example.

Global procedures

SAS programs and macros to carry out global and component tests and perform sample size calculations in the osteoarthritis trial example.

Superiority-noninferiority procedures

SAS programs and macros to carry out the Tamhane-Logan test in the Alzheimer's disease trial trial example.

Afternoon session: Gatekeeping procedures

Serial and parallel gatekeeping procedures

SAS programs and macros to compute adjusted p-values for serial gatekeeping procedures (Type II diabetes trial example) and parallel gatekeeping procedures (cardiovascular trial example).

Tree gatekeeping procedures

SAS programs and macros to compute adjusted p-values for tree gatekeeping procedure (hypertension and Type II diabetes trial examples).

More information

For more information on software implementation of commonly used multiple testing procedures and gatekeeping procedures, see Implementation of Multiple Testing Procedures and Implementation of Gatekeeping Procedures.