Dmitrienko Tamhane 2007

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Dmitrienko, A., Tamhane, A.C. (2007). Gatekeeping procedures with clinical trial applications. Pharmaceutical Statistics. 6, 171-180.


The objective of this paper is to give an overview of a relatively new area of multiplicity research that deals with the analysis of hierarchically ordered multiple objectives. Testing procedures for this problem are known as gatekeeping procedures and have found a variety of applications in clinical trials. This paper reviews main classes of these procedures, including serial and parallel gatekeeping procedures, and tree gatekeeping procedures that account for logical restrictions among multiple objectives. We focus on procedures based on marginal p-values; extensions to procedures that exploit the joint distribution of the p-values are also noted. Clinical trial examples are used to illustrate the procedures and their important properties.


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Review papers and chapters

This is a review paper which provides information on methodology and publications in this area of research as of early 2007 . For more information on gatekeeping procedures in clinical trials, see Dmitrienko Tamhane 2009 (Chapter 5 in Multiple Testing Problems in Pharmaceutical Statistics published in 2009 in the Chapman and Hall/CRC Biostatistics Series).

Other papers

For information on other publications on gatekeeping procedures in clinical trials, see Gatekeeping Papers.