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Dmitrienko Tamhane 2013

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Dmitrienko, A., Tamhane, A.C. (2013). General theory of mixture procedures for gatekeeping. Biometrical Journal. 55, 402-419.

Abstract

The paper introduces a general approach to constructing mixture-based gatekeeping procedures in multiplicity problems with two or more families of hypotheses. Mixture procedures serve as extensions of and overcome limitations of some previous gatekeeping approaches such as parallel gatekeeping and tree-structured gatekeeping. This paper offers a general theory of mixture procedures constructed from nonparametric (p-value based) or parametric (normal theory based) procedures and studies their properties. It is also shown that the mixture procedure for parallel gatekeeping is equivalent to to the multistage gatekeeping procedure. A clinical trial example is used to illustrate the mixture approach and implementation of mixture procedures.

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Review papers and chapters

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Other papers

For information on other publications on gatekeeping procedures in clinical trials, see Gatekeeping Papers.