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Multiple Testing Problems in Pharmaceutical Statistics 2008

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Half-day course taught by Alex Dmitrienko (Eli Lilly and Company) at the FDA/Industry Statistics Workshop in Crystal City, VA on September 15, 2008.

Back to Short Courses.

Textbook

Dmitrienko A, Molenberghs G, Chuang-Stein C, Offen W. Analysis of Clinical Trials Using SAS. SAS Press, 2005.

More information

For more information on software implementation of commonly used multiple testing procedures and gatekeeping procedures, see Implementation of Multiple Testing Procedures and Implementation of Gatekeeping Procedures.

References

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Dmitrienko A, Offen W, Westfall P. (2003). Gatekeeping strategies for clinical trials that do not require all primary effects to be significant. Statistics in Medicine. 22, 2387-2400.

Dmitrienko A, Molenberghs A, Christy C, Offen W. (2005). Analysis of Clinical Trials Using SAS: A Practical Guide. SAS Press.

Dmitrienko A, Tamhane A, Wang X, Chen X. (2006). Stepwise gatekeeping procedures in clinical trial applications. Biometrical Journal. 48, 984-991.

Dmitrienko A, Fritsch K, Hsu J, Ruberg S. (2007). Design and analysis of dose-ranging clinical studies. Pharmaceutical Statistics Using SAS: A Practical Guide. Dmitrienko A, Chuang-Stein C, D'Agostino R. (editors). SAS Press: Cary, NC.

Dmitrienko A, Wiens B, Tamhane A, Wang X. (2007). Tree-structured gatekeeping tests in clinical trials with hierarchically ordered multiple objectives. Statistics in Medicine. 26, 2465-2478.

Dmitrienko A, Tamhane A, Wiens B. (2008). General multistage gatekeeping procedures. Biometrical Journal. In press.

Dmitrienko A, Tamhane A, Liu L, Wiens B. (2008). A note on tree gatekeeping procedures in clinical trials. Statistics in Medicine. 27, 3446-3451.

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Wiens B. (2003). A fixed-sequence Bonferroni procedure for testing multiple endpoints. Pharmaceutical Statistics. 2, 211-215.

Wiens B, Dmitrienko A. (2005). The fallback procedure for evaluating a single family of hypotheses. Journal of Biopharmaceutical Statistics. 15, 929-942.