This web site provides general information on traditional and innovative approaches to the design and analysis of clinical trials with multiple objectives, including multiple endpoints, multiple dose-control comparisons, multiple subgroups, etc.
See Index for a list of articles on the MultXpert web site.
What is new?
Presentations on multiplicity issues and subgroup analysis in clinical trials were given at the Joint Statistical Meetings in Montreal, QC on August 4-August 8, 2013. See Multiplicity Issues in Clinical Trials JSM 2013.
Invited session on key multiplicity issues in clinical trials was held at the DIA Annual Meeting in Boston on June 24, 2013. See DIA 2013.
Invited session on multiplicity issues in clinical trials was held at the SCT Annual Meeting in Boston on May 20, 2013. See SCT 2013.
The U.S. Food and Drug Administration released a draft guidance document on enrichment strategies for clinical trials on December 17, 2012. See Regulatory Guidance.
The online lecture series on key multiplicity issues in clinical drug development organized by the QSPI Multiplicity Working Group was kicked off with a presentation by Norbert Benda, Federal Institute for Drugs and Medical Devices (BfArM), Bonn on December 13, 2012. See QSPI Multiplicity Lecture Series.
Visit Updates to get more MultXpert updates.
Multiple Testing Problems in Pharmaceutical Statistics, edited by Dr. Alex Dmitrienko (Eli Lilly and Company, U.S.A.), Prof. Ajit C. Tamhane (Northwestern University, U.S.A.) and Dr. Frank Bretz (Novartis, Switzerland; Hannover Medical School, Germany) [Chapman & Hall/CRC Press 2009]. Available on Amazon's web site.
Multiple Comparisons Using R, written by Dr. Frank Bretz (Novartis Pharma AG, Switzerland; Hannover Medical School, Germany), Prof. Torsten Hothorn (Ludwig-Maximilians-Universität München, Germany) and Prof. Peter Westfall (Texas Tech University, USA) [Chapman & Hall/CRC Press 2010]. Available on Amazon's web site.
Visit Short Courses for information on recent and upcoming short courses on multiplicity and related topics.
Visit MultXpert package to learn about the new R package for implementing popular multiple testing and gatekeeping procedures
Visit Software to find out more about other free software for implementation of commonly used multiple testing and gatekeeping procedures
This web site is maintained by a group of volunteers led by Alex Dmitrienko. We would like to thank the organizations that have generously provided funds to support this web site:
- Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Osaka.
- Applied Statistics Workshop.
- Trimodal Network.