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Multiplicity Expert

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This web site provides general information on traditional and innovative approaches to the design and analysis of clinical trials with multiple objectives, including multiple endpoints, multiple dose-control comparisons, multiple subgroups, etc.

See Index for a list of articles on the MultXpert web site.

What is new?

Special issue of Journal of Biopharmaceutical Statistics on subgroup analysis in clinical trials (January 2014) guest-edited by Sue-Jane Wang (FDA) and Alex Dmitrienko (Quintiles). See Journal of Biopharmaceutical Statistics 2014.

Presentations on multiplicity issues and subgroup analysis in clinical trials were given at the Joint Statistical Meetings in Montreal, QC on August 4-August 8, 2013. See Multiplicity Issues in Clinical Trials JSM 2013.

Invited session on key multiplicity issues in clinical trials was held at the DIA Annual Meeting in Boston on June 24, 2013. See DIA 2013.

Invited session on multiplicity issues in clinical trials was held at the SCT Annual Meeting in Boston on May 20, 2013. See SCT 2013.

Multiplicity Issues in Clinical Trials 2013 was taught by Alex Dmitrienko at the ENAR conference in Orlando, FL on March 10, 2013.

Visit Updates to get more MultXpert updates.

Books

Multiple Testing Problems in Pharmaceutical Statistics, edited by Dr. Alex Dmitrienko (Eli Lilly and Company, U.S.A.), Prof. Ajit C. Tamhane (Northwestern University, U.S.A.) and Dr. Frank Bretz (Novartis, Switzerland; Hannover Medical School, Germany) [Chapman & Hall/CRC Press 2009]. Available on Amazon's web site.

Multiple Comparisons Using R, written by Dr. Frank Bretz (Novartis Pharma AG, Switzerland; Hannover Medical School, Germany), Prof. Torsten Hothorn (Ludwig-Maximilians-Universit√§t M√ľnchen, Germany) and Prof. Peter Westfall (Texas Tech University, USA) [Chapman & Hall/CRC Press 2010]. Available on Amazon's web site.

Short courses

Visit Short Courses for information on recent and upcoming short courses on multiplicity and related topics.

Software

Visit MultXpert package to learn about the new R package for implementing popular multiple testing and gatekeeping procedures

Visit Software to find out more about other free software for implementation of commonly used multiple testing and gatekeeping procedures

Web site

This web site is maintained by a group of volunteers led by Alex Dmitrienko. We would like to thank the organizations that have generously provided funds to support this web site:

  • Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Osaka.
  • Applied Statistics Workshop.
  • Trimodal Network.