Rabbit P4HB Antibody
P4HB antibody LS-C203158 is an unconjugated rabbit monoclonal antibody to P4HB (PDI) from human. Validated for ELISA, Flow and WB.
PDI / P4HB Rabbit anti-Human Monoclonal Antibody
- Western blot (0.5 - 1 µg/ml)
- Flow Cytometry
Store at -20°C. Long term: aliquot and store at -20°C. Reconstituted: store at 2°C to 8°C for up to 3 weeks. Avoid freeze/thaw cycles.
Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, the protein seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. It may therefore cause structural modifications of exofacial proteins. Inside the cell, PDI seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity).
PDI may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.